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The onset of action is about 2 minutes after the injection.

• Paediatric patients 6 months to 5 years of age: initial dose 0.05 to 0.1 mg/kg.

Adults over 60 years of age In adults over 60 years of age, debilitated or chronically ill patients, the initial dose must be reduced to 0.5-1.0 mg and given 5-10 minutes before the beginning of the procedure.

Further doses of 0.5 to 1 mg may be given as necessary.

The intravenous injection of midazolam should be given slowly, at a rate of approx. Adults below the age of 60 In adults below the age of 60 the initial dose is 2 to 2.5 mg given 5 to 10 minutes before the beginning of the procedure. Mean total doses have been found to range from 3.5 to 7.5 mg.

A total dose greater than 5 mg is usually not necessary.